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( 2 O 2 , a potent ROS-inducer, and superoxide dismutase (SOD), a natural antioxidant agent, were higher in GO then control OFs, whereas the ROS antagonist glutathione peroxidase (GPX) was reduced, with a reduced ratio between glutathione and oxidized glutathione, suggesting the presence of a remarkable state of oxidative stress ( Glycosaminoglycan Production and Heat Shock Protein 72 Expression in Orbital fibroblasts As mentioned above, the release of GAGs plays an important role in the pathogenesis of GO

In the MAPK/ERK pathway, when the transmembrane receptors are activated, the cytoplasmic complexes of growth-factor-receptor bound protein (GRB) 2 and son of sevenless (SOS) are recruited to the inner surface of the cell membrane

doi: 10.3390/ijerph16101829 35

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For example, it is a big problem that curcumin is not easily absorbed by the body, but as emphasized in this review, eating turmeric (curcumin) and black pepper (piperine) together can make the absorption effect particularly good (117, 118)